Berezovski Research Group · University of Ottawa

Reading the molecules of disease, one signal at a time.

We build aptamers, capillary electrophoresis and mass spectrometry into tools for cancer diagnostics, imaging and therapy — from circulating tumour cells to the proteome of extracellular vesicles.

47
h-index
7,684
Citations
133
Journal articles
$8.35M
Funding as PI

Now hiring Graduate students

We welcome curious M.Sc. and Ph.D. students — in Chemistry or Chemical & Environmental Toxicology — to develop new diagnostics and therapeutics with nucleic-acid aptamers and exosomes. A fast-track to the Ph.D. is open to strong candidates after one year. Send a cover letter, CV and transcripts.

Email your application →

Open Industry partner

We are looking for an R&D-capable partner company to advance diagnostics for viruses, bacteria and cancers. Your expertise and resources would help bring joint projects from the bench toward the clinic.

Start a conversation →
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Prof. Maxim V. Berezovski
Full Professor of Chemistry & Biomolecular Sciences · Associate Director, John L. Holmes Mass Spectrometry Facility

The principal investigator

Maxim Berezovski leads the Molecular Diagnostics Laboratory in the Department of Chemistry and Biomolecular Sciences at the University of Ottawa, in the heart of Canada's capital.

His group works at the meeting point of bioanalytical chemistry and clinical need: selecting DNA and RNA aptamers against live cells, viruses and tumour markers; measuring biomolecular interactions in solution by kinetic capillary electrophoresis coupled to mass spectrometry; and mapping the proteome and metabolome of extracellular vesicles for cancer biomarker discovery. The throughline is turning precise molecular measurement into diagnostics, imaging and therapy.

Trained at York University under Sergey Krylov, Berezovski has published more than 130 peer-reviewed articles, holds three patents, and has been principal investigator on over CAD $8 million in research funding.

2025–26
Humboldt Senior FellowshipUniversity of Bayreuth Centre of International Excellence "Alexander von Humboldt", Germany
2025
W. A. E. McBryde MedalCanadian Society for Chemistry — for significant achievement in analytical chemistry
2019
Friedrich Wilhelm Bessel Research AwardAlexander von Humboldt Foundation, Germany
2018
Visiting ProfessorshipRoyal Netherlands Academy of Arts and Sciences · Leiden University Medical Center
2014
Young Researcher of the YearUniversity of Ottawa

Research

Three programs, one instrument philosophy

Every project begins with measuring molecules accurately — and ends with a tool a clinician or a fellow scientist can actually use.

01

Capillary Electrophoresis & Mass Spectrometry

The platform behind Berezovski's Ph.D. and the lab's core craft: CE–MS for the conformational dynamics and affinity interactions of DNA and proteins, and for enzyme and substrate discovery.

  • Simultaneous protein structure & activity in one run (Nat. Chem. Biol. 2016)
  • Protein-facilitated affinity CE for ultralow microRNA in serum
  • Kinetic CE–MS for weak, fast noncovalent interactions
02

Aptamers for Biosensing & Molecular Therapy

From selecting new DNA/RNA aptamers and mapping their 3D structure to biosensors, in vivo imaging and theranostics.

  • Aptamers against tumour cells, CTCs, viruses and bacteria
  • ¹¹C-radiolabeled aptamer PET/CT imaging of tumours
  • Aptamer fluorescence-guided surgery of brain tumours (JACS 2024)
  • Switchable aptamers for virus & cell purification (US patent)
03

Proteomics & Metabolomics of Extracellular Vesicles

Affinity isolation and deep analysis of EV cargo to find what cancer cells broadcast to the body.

  • EVqCE — quantitative CE for EV concentration & RNA mass
  • Exosomal proteome of breast cancer (Sci. Rep. — Top 100 in Cancer)
  • Phospho- and lysine-acetyl maps of cancer-derived sEVs
  • Functional metabolic enzymes carried by microvesicles

Selected publications

Recent & high-impact work

A curated slice of 130+ peer-reviewed articles. The full, current list lives on Google Scholar.

The team

Who's in the lab

A group of chemists, biochemists and analysts spanning four continents.

MB
Maxim Berezovski
Principal Investigator
ZM
Dr. Zoran Minic
Proteomics Manager
Mass spectrometry core
PK
Petr Kasyanchyk
Ph.D. Student
SR
Aliaksandra Radchanka
Ph.D. Student
JT
Jessica Pham Tran
Ph.D. Student
AK
Abdullah Khraibah
Ph.D. Student
AK
Andrew Kenney
Ph.D. Student
Co-supervised, Health Canada
YL
Yingxi (Cici) Li
Research Assistant
JC
Jake Campbell
M.Sc. Student
ML
Maui Lintag
M.Sc. Student

Undergraduate honours researchers · 2026

Firelle Kouz Ganna Elgohary Kyle Côté Lexandra Monkam Margaret Kravchenko Zaineb Dachraoui

Since 2009, the lab has trained 7 postdoctoral fellows, 7 Ph.D. and 15 M.Sc. graduates, and more than 55 undergraduate researchers — now working across academia and industry worldwide.

Facilities

The instruments behind the science

A bioanalytical suite built for separation, detection and identification of biomolecules.

Mass Spectrometry

  • Thermo Orbitrap Fusion TribridnanoLC · ETD · resolution to 500,000 · proteomics & PTMs
  • Thermo Q Exactive PlusnanoLC · hybrid quadrupole-Orbitrap · metabolomics & MALDI imaging
  • Waters SYNAPT G2 HDMSion mobility–TOF coupled to Beckman PA800plus CE

Capillary Electrophoresis

  • Beckman PA800plusMS-coupled separation
  • ProteomeLab PA800 · P/ACE MDQUV, LIF & PDA — aptamer selection
  • Lumex CAPEL-205UV · cannabinoids, amino acids & small metabolites

Interaction & Detection

  • Sartorius / FortéBio BLItzbiolayer interferometry — aptamer kinetics & Kd
  • Molecular Devices FilterMax F5multi-mode plate reader · fluorescence polarization
  • Alpha Innotech FluorChem Qchemiluminescence & fluorescence imaging

Molecular Biology & Purification

  • ÄKTA Prime FPLCrecombinant protein production
  • Lumex AriaDNA · thermal cyclersmicrochip real-time PCR
  • Qubit 4 · NanoDrop One · iBlot 2 / iBindquantitation & automated western blotting

Teaching

Courses at uOttawa

CHM 2354

Analytical Chemistry

Undergraduate · the foundations of quantitative measurement, with laboratories.

BCH 4116 / BIM 4316

Modern Bioanalytical Chemistry

Senior undergraduate · analysis of biomolecules and their interactions, with laboratories.

CHM 8352

MS-Based Proteomics

Graduate · analytical approaches to chemical problems, co-instructed with Dr. Zoran Minic.

Over 3,400 students taught since 2009.

Get in touch

Join the lab, or build something with us.

Prospective students, collaborators and industry partners are all welcome. The fastest way to reach us is a direct email.

Email Prof. Berezovski
AddressDepartment of Chemistry & Biomolecular Sciences
University of Ottawa
10 Marie-Curie, D'Iorio Hall, Room 201
Ottawa, Ontario, Canada  K1N 6N5
LaboratoryMarion Hall, rooms MRN02 & DRO124G
Phone(613) 562-5800 ext. 1898